en عمومى General پژوهشي Research <div style="border:double windowtext 1.5pt; padding:1.0pt 4.0pt 1.0pt 4.0pt"><span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Background: </span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Given that no comprehensive study was conducted regarding the effect of sodium chloride on the prevention of mucormycosis fungal infection in acute leukemia patients during treatment, this study aimed the investigating the effect of sodium chloride&nbsp; on the prevention of mucormycosis fungal infection in acute lymphocytic leukemia patients during treatment.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Materials and Methods: </span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">This retrospective study was conducted on children with ALL who were undergoing chemotherapy in the induction phase and were susceptible to fungal and infectious diseases. Then 84 patients were randomly divided into the two groups. One group (n=46) received nasal drop containing sodium chloride (NORMONIX, 0.65%, three times a day) as the intervention group during treatment and another group did not receive sodium chloride (control group)(n=38). If the symptoms of mucormycosis was observed and detected (positive test), the injection of amphotrypsin B was started.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Results: </span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">In the current study, 84 patients entered the study.&nbsp; The mean age of patients in the control group and the intervention group was 7.84&plusmn;3.45, and 6.45&plusmn;3.4 years, respectively (P>0.05). Positive mucormycosis was seen in 24 (63.2%) patients in the control group and 16 (34.78%) patients in the intervention group (P=0.01). </span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Conclusion: </span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">According to the findings of this study, the frequency of patients with positive mucormycosis in the NaCl group was significantly lower than the control group.&nbsp; Therefore, it seems that NaCl drop can be effective regarding reducing the incidence of mucormycosis fungal infection and can decrease the need to amphotrypsin B, but further studies should be conducted in this regard. </span></span></span></span></span></div> Mucormycosis fungal, Prevention, Sodium chloride 7 12 http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-1004-1&slc_lang=en&sid=1 Yasaman Ghodsi boushehri Yasamn.Boushehriii@gmail.com 0000-0001-5914-1979 No Shiraz University of Medical Sciences, Shiraz, Iran Shiraz University of Medical Sciences, Shiraz, Iran Ehsan Zare Sangderazi ZareSangderazi2@gmail.com 0000-0001-2134-4554 No Medical doctor, Faculty of Medicine, Shahid Sadoughi University of Medical sciences, Yazd, Iran Medical doctor, Faculty of Medicine, Shahid Sadoughi University of Medical sciences, Yazd, Iran Morteza Zaboli Mahdiabadi Zabolimehdiabadiii@gmail.com 0000-0001-8765-3423 No Medical doctor, Faculty of Medicine, Shahid Sadoughi University of Medical sciences, Yazd, Iran Medical doctor, Faculty of Medicine, Shahid Sadoughi University of Medical sciences, Yazd, Iran Seyed Mohammad Amin Hashemipour Hashemipourseyedmohamadd@gmail.com 0000-0002-2343-2344 No Young Researches and Elites Club, Faculty of Medicine, Islamic Azad University, Yazd Branch, Yazd, Iran Young Researches and Elites Club, Faculty of Medicine, Islamic Azad University, Yazd Branch, Yazd, Iran Sima Mozafari simsam11@gmail.com 0000-0003-4960-2718 No Hematology and Oncology Research Center, Shahid Sadoughi University of Medical sciences, Yazd, Iran Hematology and Oncology Research Center, Shahid Sadoughi University of Medical sciences, Yazd, Iran Marzieh Sattar Marziehsattar5@gmail.com 0000-0002-2343-4312 No Young Researches and Elites Club, Faculty of Medicine, Islamic Azad University, Yazd Branch, Yazd, Iran Young Researches and Elites Club, Faculty of Medicine, Islamic Azad University, Yazd Branch, Yazd, Iran Farimah Shamsi Farimahshamsi@gmail.com 0000-0000-0000-0000 No Center of Healthcare Data Modeling, Department of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical sciences, Yazd, Iran Center of Healthcare Data Modeling, Department of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical sciences, Yazd, Iran Azam Hashemi azamhashemi201999@gmail.com 0000-0003-4468-5884 Yes Hematology and Oncology Research Center, Shahid Sadoughi University of Medical sciences, Yazd, Iran Hematology and Oncology Research Center, Shahid Sadoughi University of Medical sciences, Yazd, Iran