Iranian journal of Pediatric Hematology and Oncology

en Impact of Vitamin D Supplementation on Pain Management in Sickle Cell Disease Patients عمومى General پژوهشي Research <div style="border: 1.5pt double windowtext; padding: 1pt 4pt; text-align: justify;">Background: Vitamin D deficiency is prevalent among patients with sickle cell disease, regardless of their age or the season. Since there has been no extensive research on the impact of vitamin D on pain in sickle cell disease, this study aimed to evaluate how vitamin D supplementation influences pain management in these patients. Materials and Methods: This retrospective study was conducted on children (12.3±4.45 years old) with definitive diagnosis of sickle cell. The study was done in the Department of Oncology of Shahid Sadoughi Hospital, Yazd, Iran, over the years 2019-2021. Thirty patients (14 boys and 16 girls) with vitamin D insufficiency and deficiency entered the study and 50000 IU vitamin D was given weekly for 16 weeks. The measurement of vitamin 25(OH) D3 before and after intervention was done by ELISA method (Monobind kit, USA). Pain intensity assessment was also done. Other relevant data were extracted from the patients’ medical records. Results: In this study, amomg 30 patients, 46.6% of them had vitamin D deficiency. A significant reduction in pain intensity was observed in patients following the intervention (p<0.05). Conclusion: Based on the findings of this study, vitamin D was effective in reducing pain intensity in these patients. Therefore, vitamin D can be used in the pain management of these patients.</div> Pain, Sickle cell disease, Vitamin D supplementation 276 281 http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-795-3&slc_lang=en&sid=1 Ehsan Rezaeinezhad ehhssannrezaei@gmail.com 0000-0002-5156-6659 No Yazd Branch, Islamic Azad University, Yazd, Iran Yazd Branch, Islamic Azad University, Yazd, Iran Morteza Zangeneh Soroush mortezazangennehsorous@gmil.com 0000-0001-7117-564x No Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran Fatemeh Poorhosseini fattemmehpourhosseini@gmail.com 0000-0001-8261-2251 No Shahid Sadoughi University of Medical Sciences, Yazd, Iran Shahid Sadoughi University of Medical Sciences, Yazd, Iran Azam Hashemi drazamhashemi@yahoo.com 0000-0002-1725-2007 Yes Hematology and oncology research center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Hematology and oncology research center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran