Iranian journal of Pediatric Hematology and Oncology

en Frequency of Red Cell Alloimmunization in Patients with Thalassemia Major: A Report from the Southwest of Iran هماتولوژی Hematology پژوهشي Research <div style="border:double windowtext 1.5pt; padding:1.0pt 4.0pt 1.0pt 4.0pt">Background: The mainstay of managing severe β-thalassemia remains lifelong blood transfusion. Mismatched red blood cell phenotypes between donors and recipients in multiple blood transfusions can result in the development of alloimmunization in recipients. The aim of this study was to determine the frequency of major and subgroup antigens and their phenotypes in thalassemia major patients. Materials and Methods: This cross-sectional descriptive study was performed on 105 patients with thalassemia major who referred to Baghaei Hospital in Ahvaz in 2021. Their alloimmunization to erythrocyte antigens was determined with standard tubular antibody search kits. Results: Among the thalassemia major patients participating in the study, 51 were female (48.45%). The mean age of the participants was 21.10 ± 5.8 years. Out of the 105 patients studied, 26 had detectable alloantibodies in the serum (24.7%). The two groups of patients with positive and negative alloantibodies were significantly different in terms of Rh and C blood groups (P-values of 0.03 and 0.05, respectively). There was no significant association between the existence alloantibody and age, gender, spleen condition and the time of first transfusion (P > 0.05). Conclusion:  It was concluded that red blood cell matching, at least for Rh and C groups, is necessary to prevent alloimmunization in thalassemia major patients.</div> Alloimmunization, Major thalassemia, Transfusion 260 268 http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-1047-1&slc_lang=en&sid=1 Bijan Keikhaei keikhaei@gmail.com 0000-0002-3087-7650 No Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Homayoun Yousefi yousefihomayoon@gmail.com 0000-0003-3482-2195 No Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Arash Alghasi alghasi@yahoo.com 0000-0002-3482-2195 No Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Asaad Sharhani asadsharhani@gmai.com 0000-0001-9277-7447 No Department of Epidemiology and Biostatistics, school of Health, Social determinants of health research center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, Department of Epidemiology and Biostatistics, school of Health, Social determinants of health research center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, roya Khazaei karami.9926@gmail.com 0009-0006-5262-8694 Yes Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.