en عمومى General مروری Review <div style="border:double windowtext 1.5pt; padding:1.0pt 4.0pt 1.0pt 4.0pt"><span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">&Beta;-thalassemia is the severe form of genetic illnesses which decreases the hemoglobin synthesis. One of the major complications in thalassemic syndromes, including &beta;-thalassemia major and intermedia is thromboembolic events. In addition, thromboembolic events are more common in non-transfusion-dependent thalassemia than those in well-transfusion-dependent &beta;-thalassemia. A combination of hypercoagulable states including, abnormalities in red blood cells, and platelet, antithrombin III, protein C, and protein S, and splenectomy are involved in thrombotic events, but thromboembolic events can be prevented and treated in these patients via blood transfusion, hydroxyurea, anticoagulants, and aspirin. Moreover, recent studies have demonstrated the involvement of the brain lesion in &beta;-thalassemia patients. The involvement of vascular events of brain in patients with &beta;-thalassemia intermedia is 29-83%, but the rate of asymptomatic brain lesions in the healthy people is 0-11%. In addition, neurological complications which have been attributed to various factors are chronic hypoxia, iron overload, bone marrow expansion, and desferrioxamine neurotoxicity. This review evaluated thromboembolic events and neurological lesions in patients with &beta;-thalassemia and its probable curative therapy. &nbsp;</span></span></span></span></span></div> Brain lesion, Thalassemia, Thromboembolic events 269 276 http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-1065-1&slc_lang=en&sid=1 Negin Kheiri neginkkeirii@gmail.com 0001-0000-6244-385x No Deparment of Internal medicine, Shiraz University of Medical Sciences, Shiraz, Iran Deparment of Internal medicine, Shiraz University of Medical Sciences, Shiraz, Iran Morteza Zangeneh Soroush mortezzazangenneh@gmail.com 0000.0002-4531-2134 No Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran Marzieh Aboutobi marziehaboutorabi209999@gmail.com Yes Department of Neurology, Shahid Sadoughi hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Department of Neurology, Shahid Sadoughi hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran