Iranian journal of Pediatric Hematology and Oncology

en A retrospective survey on follow-up of splenectomy patients due to β-thalassemia and Sickle cell Anemia in Karbala, Iraq during 2010-2023 هماتولوژی Hematology پژوهشي Research <div style="border:double windowtext 1.5pt; padding:1.0pt 4.0pt 1.0pt 4.0pt">Background: Hemoglobinopathy is considered a common monogenetic genetic disorder worldwide. Splenectomy is considered a therapeutic strategy in patients with hemoglobinopathy. The aim of current study was to provide a survey on the splenectomy and 5 years follow-up in different clinical forms of β-thalassemia (intermedia, Major) and Sickle cell Anemia (SCA) patients who referred to Hereditary Blood Disease Center in the Karbala Teaching Hospital for Children in Karbala, Iraq. Materials and Methods: In this retrospective study we tried to evaluate 126 hemoglobinopathy and thalassemia patients from Karbala City, Iraq. All cases of splenectomy due to hemoglobinopathy and thalassemia during 2010-2023 who referred to the Hereditary Blood Disease Center in the Karbala Teaching Hospital for Children in Karbala, Iraq were included. Patient data was collected at three-time points. The first was after the splenectomy, the second during 1-5 years, and the third step after 5 years.  Clinical and laboratory data were retrieved from the patient’s file. Results: The mean age of splenectomy of included patients was 14.1±7.5 years. From 126 cases, 103 (81.74%) were β-Thalassemia, 13 (10.32%) were SCA, and 10 (7.94%) were Sickle cell beta-thalassemia. The mean age in SCA was significantly less than two other groups (mean age in β-Thalassemia, SCA and Sickle cell beta thalassemia were 18.2±8.7, 24.2±12.7 and 25.2±9.5, respectively) (p=0.008). Platelet and WBC count represents a significant increase during 1-5 years after splenectomy in comparison with 1 year after splenectomy (for Platelet and WBC p=0.03 and 0.001, respectively). Conclusion: splenectomy is considered the last therapeutic option in hemoglobinopathy patients. All Hemoglobinopathy patients represented significant improvement after splenectomy. Because there was no suitable treatment in the past, splenectomy was considered a therapeutic solution. It should be said that periodic follow-up of splenectomy patients in hemoglobinopathy plays an important role in improving the management of these diseases.</div> β-thalassemia, Hemoglobinopathy, Sickle cell Anemia 196 204 http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-1087-1&slc_lang=en&sid=1 Inas Muayad Mohammed Ali alshemmaryinas@gmail.com 0000-0001-6733-9736 Yes Department of Pediatrics, College of Medicine, University of Kerbala, Karbala, Iraq Department of Pediatrics, College of Medicine, University of Kerbala, Karbala, Iraq Ashwaq Ali Hussein ashwaqalbalhawi@gmail.com No Department of Pediatrics, College of Medicine, University of Kerbala, Karbala, Iraq Department of Pediatrics, College of Medicine, University of Kerbala, Karbala, Iraq Israa Mustafa Salih Al-Musawi israe.m.s@gmail.com No Karbala Teaching Hospital for Children, Karbala, Iraq Karbala Teaching Hospital for Children, Karbala, Iraq