Iranian journal of Pediatric Hematology and Oncology

en A Compound Heterozygous of Hb E and Beta Thalassemia Independent of Transfusion: A Rare Case Report عمومى General گزارش مورد case report <div style="border: 1.5pt double windowtext; padding: 1pt 4pt 1pt 0cm; text-align: justify;">Hemoglobinopathy is now a worldwide problem. Mainly described in Southeast Asian countries. A compound heterozygous form of hemoglobin (Hb) E & β thalassemia was reported to be 50% of all severe forms of thalassemia. Clinical presentation of HbE/ b thalassemia is reported to be moderate to severe anemia. The children usually present at the age range of 7 months to 6.9 years. The clinical severity is affected by genetic factors, including mutation in a chain (β thalassemia), alpha-chain (a thalassemia), amount of adult Hb, and co-inheritance of another hemoglobinopathy. Here, we present a rare case of compound heterozygous of HbE/ β thalassemia), who survived without transfusion and complication until eight years of age. Peripheral blood smears and complete blood count showed microcytic hypochromic anemia.  High-performance chromatography showed a compound heterozygous of HbE/ β thalassemia.</div> β thalassemia, Compound, Hemoglobin E, Heterozygous, Transfusion 315 319 http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-1063-1&slc_lang=en&sid=1 Anju Khairwa anjukhairwa@gmail.com 0000-0001-8514-422X Yes Departments of Pathology, University College of Medical Sciences & GTB hospital, Delhi Departments of Pathology, University College of Medical Sciences & GTB hospital, Delhi Mrinalini Kotru mrinalini.kotru@gmail.com 0000-0001-6779-6814 No Departments of Pathology, University College of Medical Sciences & GTB hospital, Delhi Departments of Pathology, University College of Medical Sciences & GTB hospital, Delhi Pooja Dewan poojadewan@hotmail.com 0000-0002-7373-5679 No Departments of Pathology, University College of Medical Sciences & GTB hospital, Delhi Departments of Pathology, University College of Medical Sciences & GTB hospital, Delhi