Iranian journal of Pediatric Hematology and Oncology

en Comparison of the Volumetric Parameters of Platelets in Diabetic Children with and without Diabetic Ketoacidosis: A Case-Control Study in the North of Iran عمومى General پژوهشي Research <div style="border: 1.5pt double windowtext; padding: 1pt 4pt; text-align: justify;">Background: This study aimed to determine the volumetric parameters of platelets including MPV (Mean Platelet Volume) and PDW (Platelet Distribution Width) in diabetic children with and without diabetic ketoacidosis (DKA) and to evaluate their relationship with the severity of DKA. Materials and Methods: A case-control study was conducted on 112 children with type 1 diabetes mellitus (T1DM), with and without DKA, who referred to Amirkola Children's Hospital, Iran, in 2016-2021. Of them, 43 were boys, and 69 were girls. The diagnosis of diabetes was based on clinical symptoms and diagnostic criteria, and DKA was diagnosed through the analysis of arterial blood gas. The patients’ MPV and PDW were also evaluated, and the P values less than 0.05 were considered significant. Results: Out of 112 children with diabetes (with the mean age of 8.71 ± 3.22 years), 56 persons had DKA.  In terms of DKA severity, 17 patients (30.4%) had mild, 29 (51.8%) had moderate, and 10 (17.8%) had severe DKA. The children with DKA had the mean blood glucose of 490.98±46.11mg/dL, MPV of 10.02± 1.19fl), and PDW of 13.07± 1.18flwere significantly higher (P<0.001). It was found that, an increase in the severity of DKA would raise the mean MPV (P = 0.006) and PDW(P<0.001) significantly. Conclusion: Based on the results of this study, as the severity of DKA increases in diabetic children, the mean levels of MPV and PDW increase significantly. Therefore, it is suggested that MPV and PDW be used to predict the severity of DKA in diabetic children.</div> Diabetes mellitus type 1, Diabetic ketoacidosis, Mean platelet volume 282 290 http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-1131-1&slc_lang=en&sid=1 Fatemeh Mirdoosti fmirdoosti@gmail.com 0009-0005-0805-0066 No Student Research Committee, Babol University of Medical Sciences, Babol, Iran Student Research Committee, Babol University of Medical Sciences, Babol, Iran Hassan Mahmoodi Nesheli mahmoodi86@yahoo.com 0000-0002-5851-7323 No Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IR Iran Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IR Iran Hoda Shirafkan hodashirafkan@gmail.com 0000-0002-5682-1153 No Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran sajedeh Hajipour hajipour1365@gmail.com 0000-0001-8527-9757 No Clinical Research Development Unit of Amirkola Children's Hospital, Babol University of Medical Sciences, Babol, IR Iran Clinical Research Development Unit of Amirkola Children's Hospital, Babol University of Medical Sciences, Babol, IR Iran Pouria Alijanpour Pouriaalijanpour@gmail.com 0000-0001-9569-564X No Student of Research Committee ,School of Health Management & Information Science ,Shiraz University of Medical Sciences, Shiraz, Iran. Student of Research Committee ,School of Health Management & Information Science ,Shiraz University of Medical Sciences, Shiraz, Iran. Mohammad Pournasrollah pornasrollah@yahoo.com 0000-0002-3161-1440 No Clinical Research Development Unit of Amirkola Children's Hospital, Babol University of Medical Sciences, Babol, IR Iran Clinical Research Development Unit of Amirkola Children's Hospital, Babol University of Medical Sciences, Babol, IR Iran Morteza Alijanpour m.alijanpour@yahoo.com 0000-0002-0031-4718 Yes Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IR Iran Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IR Iran