Iranian journal of Pediatric Hematology and Oncology

en The Effect of Iron Therapy on Electrocardiography Parameters in Children with Iron Deficiency Anemia هماتولوژی Hematology پژوهشي Research <div style="border: 1.5pt double windowtext; padding: 1pt 4pt; text-align: justify;">Background: Iron is essential for hemoglobin (Hb) production and the body's ability to transport oxygen. This study aimed to evaluate the impact of iron deficiency anemia (IDA) on electrocardiographic (ECG) parameters in children. Materials and Methods: This pre–post interventional study was carried out at Ali Asghar Hospital in Zahedan and included children aged 5 to 18 years diagnosed with IDA. For each participant, hematologic markers Hb, ferritin, serum iron, and total iron-binding capacity (TIBC) were assessed. In addition, ECG indices, including P wave duration (PWd), QT interval dispersion (QTd), corrected QT interval (QTc), Tp-e interval, and Tp-e dispersion, were recorded both at baseline and after three months of iron therapy. Results: A total of 45 children (mean age: 11.47 ± 4.00 years) participated in the study. After three months of treatment with 4–6 mg/kg/day of elemental iron, significant improvements were observed in several hematological and ECG parameters, including ferritin, serum iron, TIBC, P wave duration, P wave dispersion, QTc, QTc dispersion, Tp-e interval, Tp-e dispersion, and the Tp-e/QTc ratio (p < 0.001). In children with Hb levels between 10 and 11 g/dL, all ECG parameters improved significantly (p < 0.001), while those with Hb levels between 8 and 9 g/dL showed significant improvement in all parameters except the Tp-e/QTc ratio (p = 0.002). Among children with ferritin levels >10 ng/mL, all ECG parameters improved (p < 0.001), whereas in those with ferritin ≤10 ng/mL, all but QTc showed significant changes (p =0.002). Serum iron levels between 15 and 20 µg/dL were associated with improvements in all evaluated parameters (p = 0.002), while those with levels between 21 and 28 µg/dL demonstrated significant changes only in TIBC and P wave duration (p = 0.002). Conclusion: The study concluded that the Iron supplementation positively impacts hematological and ECG parameters, supporting heart health in children.</div> Children, Electrocardiography, Iron Deficiency Anemia 647 660 http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-138-5&slc_lang=en&sid=1 Noor Mohammad Noori Noor Mohammad Noori dr_noori_cardio@yahoo.com 0000-0002-0732-6412 No Professor of Pediatric Cardiology, Children and Adolescents Health research center, Research Institute of cellular and Molecular Science in Infectious Diseases, Zahedan University of Medical Science's, Zahedan, Iran Professor of Pediatric Cardiology, Children and Adolescents Health research center, Research Institute of cellular and Molecular Science in Infectious Diseases, Zahedan University of Medical Science's, Zahedan, Iran Ghasem Miri Aliabad Ghasem Miri Aliabad ghmiri1357@gmail.com 0000-0002-9112-5567 No Professor of Pediatric Hematology and Oncologist, Pediatric ward, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Professor of Pediatric Hematology and Oncologist, Pediatric ward, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Tahereh Boryri Tahereh Boryri Boryri_tahereh@yahoo.com 0000-0001-7897-1884 No Instructor of Midwifery, Department of Midwifery, School of Nursing and Midwifery, Pregnancy Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran Instructor of Midwifery, Department of Midwifery, School of Nursing and Midwifery, Pregnancy Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran Leila Teimouri Leila Teimouri leila.teimouri62@gmail.com 0000-0003-2033-6225 No Teacher, MSc in Sport Physiology, Education Department of Lamerd County, Fars Province, Iran Teacher, MSc in Sport Physiology, Education Department of Lamerd County, Fars Province, Iran Sahar Sapour Moghadam Sahar Sapour Moghadam safapour_sahar@yahoo.com 0000-0002-5104-4412 No Pediatric resident, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran Pediatric resident, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran Alireza Teimouri Alireza Teimouri alirezateimouri260@gmail.com 0000-0002-8356-4260 Yes Associate Professor of Demography, Children and Adolescents Health research center, Research Institute of cellular and Molecular Science in Infectious Diseases, Zahedan University of Medical Science's, Zahedan, Iran Associate Professor of Demography, Children and Adolescents Health research center, Research Institute of cellular and Molecular Science in Infectious Diseases, Zahedan University of Medical Science's, Zahedan, Iran