Iranian journal of Pediatric Hematology and Oncology

en Congenital Neuroblastoma with a Progressive Course in a Neonate اطفال pediatrics گزارش مورد case report Background: Neuroblastoma can arise throughout the sympathoadrenal axis. It is one of the most common extracranial solid tumors in children, which accounts for about 6-10 % of all childhood cancers. Congenital neuroblastoma accounts for 5% of total neuroblastoma cases and is mostly diagnosed in the neonatal period. Treatment is individualized, and prognosis depends on many factors, including the grade of tumor.  In the neonatal period, most cases of this condition regress spontaneously, with a good prognosis. Case Presentation: A male infant born at 37 weeks of gestation with a birth weight of 3580 grams was admitted to our emergency service on the 19th day of his life. He had abdominal distention that started when the baby was 11 days old, which increased for the next five days. The case was considered to have infantile colic in another clinic and was followed until he was admitted to our hospital. Then, imaging techniques were used, and he was diagnosed with congenital neuroblastoma with massive hepatic involvement. The diagnosis was confirmed by pathologic evaluation in our Neonatal Intensive Care Unit (NICU). He was intubated until he died on the 38th day of his life due to disseminated intravascular coagulation and shock without responding to chemotherapy. Conclusion: We want to emphasize that abdominal distention in the neonatal period should be evaluated carefully to diagnose and treat such life-threatening diseases as neuroblastoma.    Abdomen, Anaplastic Lymphoma Kinase, MYCN Proto-Oncogene Protein, Neuroblastoma 1092 1098 http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-1188-1&slc_lang=en&sid=1 Fatma Cakmak Celik Fatma Cakmak Celik clkfatma@yahoo.com 0000-0002-6833-9786 Yes Neonatologist, Department of Pediatrics, Neonatology Division, University of Health Sciences, Hamidiye International Medical Faculty, Kartal Dr Lutfi Kirdar City Hospital, Istanbul, Türkiye Neonatologist, Department of Pediatrics, Neonatology Division, University of Health Sciences, Hamidiye International Medical Faculty, Kartal Dr Lutfi Kirdar City Hospital, Istanbul, Türkiye Fatma Kaya Narter Fatma Kaya Narter fatmakaya06@yahoo.com.tr 0009-0007-0796-7408 No Neonatologist, Department of Pediatrics, Neonatology Division, University of Health Sciences, Hamidiye International Medical Faculty, Kartal Dr Lutfi Kirdar City Hospital, Istanbul, Türkiye Neonatologist, Department of Pediatrics, Neonatology Division, University of Health Sciences, Hamidiye International Medical Faculty, Kartal Dr Lutfi Kirdar City Hospital, Istanbul, Türkiye Asli Turgutoglu Yilmaz Asli Turgutoglu Yilmaz asli_drdr@hotmail.com 0000-0002-2320-8766 No Department of Pediatrics, Hematology and Oncology Division, University of Health Sciences, Hamidiye International Medical Faculty, Kartal Dr Lutfi Kirdar City Hospital, Istanbul, Türkiye Department of Pediatrics, Hematology and Oncology Division, University of Health Sciences, Hamidiye International Medical Faculty, Kartal Dr Lutfi Kirdar City Hospital, Istanbul, Türkiye Emine Caliskan Emine Caliskan eminecaliskanrad@gmail.com 0000-0001-9869-1396 No Department of Radiology, University of Health Sciences, Hamidiye International Medical Faculty, Kartal Dr Lutfi Kirdar City Hospital, Istanbul, Türkiye Department of Radiology, University of Health Sciences, Hamidiye International Medical Faculty, Kartal Dr Lutfi Kirdar City Hospital, Istanbul, Türkiye Yilmaz Ay Yilmaz Ay dryilmazay@gmail.com 0000-0002-5525-5647 No Department of Pediatrics, Hematology and Oncology Division, University of Health Sciences, Hamidiye International Medical Faculty, Kartal Dr Lutfi Kirdar City Hospital, Istanbul, Türkiye Department of Pediatrics, Hematology and Oncology Division, University of Health Sciences, Hamidiye International Medical Faculty, Kartal Dr Lutfi Kirdar City Hospital, Istanbul, Türkiye Canan Ceran Özcan Canan Ceran Özcan cceran@yahoo.com 0000-0002-2014-9246 No Department of Pediatric Surgery, University of Health Sciences, Hamidiye International Medical Faculty,Kartal Dr Lutfi Kirdar Education and Research Hospital, Istanbul, Türkiye Department of Pediatric Surgery, University of Health Sciences, Hamidiye International Medical Faculty, Kartal Dr Lutfi Kirdar Education and Research Hospital, Istanbul, Türkiye Aysen Guler Aysen Guler dr.aysengencoglu@gmail.com 0009-0009-3178-6791 No Department of Pathology, Kartal Dr Lutfi Kirdar Education and Research Hospital, Istanbul, Türkiye Department of Pathology, Kartal Dr Lutfi Kirdar Education and Research Hospital, Istanbul, Türkiye