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:: Volume 3, Issue 1 (3-2013) ::
Iran J Ped Hematol Oncol 2013, 3(1): 11-6 Back to browse issues page
Effect of two Different Concentrations of Propofol and Ketamine Combinations (Ketofol) in Pediatric Patients under Lumbar Puncture or Bone Marrow Aspiration
V Ayatollahi MD , A Ghadami Yazdi MD, A Hashemi MD, SH Behdad MD, E Ghadami Yazdi MD
Abstract:   (2834 Views)
Abstract Background Ketamine is an anesthetic drug that is importantly analgesic without respiratory depression. Ketamine increases blood pressure and heart rate. Propofol is an anesthetic drug with good sedation, rapid recovery, but it causes respiratory depression, low heart rate and low blood pressure. Combination of Ketamine and Propofol provides sedation, analgesia and rapid recovery with hemodynamic stability and minimal respiratory depression. The aim of this study was to compare two different combinations of these two drugs to reach necessary sedation scale for the Lp or BMA in pediatric with ALL. Materials and Methods This randomized, double blinded study was designed to compare the quality of sedation and side effects of intravenous Ketofol on 60 patients of both gender. Patients received titrated injection of a solution containing combination of one part of Ketamine and two parts of Propofol (1:2) (group I) or one part of Ketamine and three parts of Propofol (1:3) (group II) to reach almost near 5 sedation level (using Ramsay Sedation Scale). Respiratory and hemodynamic profiles, amount of drug injected and side effects were recorded. Results These drug combinations were used on 60 children with a median age of 6.2 years. In this study, recovery time and hallucination was significantly high in group I, but in both groups hemodynamic were stable, amnesia was enough, and there was no respiratory depression. Conclusion Lower doses of Ketamine in these combinations have lower psycho mimetic side effects, and shorter recovery time.
Keywords: Key words Ketamine, Propofol, Spinal Puncture, Pediatrics
Full-Text [PDF 129 kb]   (1107 Downloads)    
Type of Study: Research | Subject: Special
Received: 2013/03/9
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Ayatollahi V, Ghadami Yazdi A, Hashemi A, Behdad S, Ghadami Yazdi E. Effect of two Different Concentrations of Propofol and Ketamine Combinations (Ketofol) in Pediatric Patients under Lumbar Puncture or Bone Marrow Aspiration. Iran J Ped Hematol Oncol. 2013; 3 (1) :11-6
URL: http://ijpho.ssu.ac.ir/article-1-100-en.html

Volume 3, Issue 1 (3-2013) Back to browse issues page
Iranian Journal of Pediatric Hematology and Oncology
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