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:: Volume 3, Issue 1 (3-2013) ::
Iran J Ped Hematol Oncol 2013, 3(1): 46-41 Back to browse issues page
Homozygous delta-beta Thalassemia in a Child: a Rare Cause of Elevated Fetal Hemoglobin
R Gupta M.D , S Verma MD, M Bhargava MD, SK Mittal MD
Abstract:   (3670 Views)
Abstract Background Delta beta (δβ) thalassemia is an unusual variant of thalassemia with elevated level of fetal hemoglobin (HbF). Homozygous patients of this disorder, unlike β-thalassemia, show mild anemia. Only few cases of δβ-thalassemia have been reported from India in the available indexed English literature. Case presentation A four-year old male child was evaluated for recent-onset jaundice. Hematological investigations showed mild anemia with microcytic hypochromic red cells. A comprehensive analysis of hemoglobin by high-performance liquid chromatography (HPLC) showed complete absence of HbA and HbA2 with HbF constituting 100% of the hemoglobin. Hemoglobin analysis of both parents showed elevated level of HbF with normal HbA2. A final diagnosis of δβ-thalassemia in the child with both parents being carriers was rendered. Conclusion Delta beta-thalassemia is an uncommon cause of markedly elevated fetal hemoglobin beyond fetal period. Clinical and haematological parameters should be evaluated to render an accurate diagnosis.
Keywords: Key Words Delta-Beta Thalassemia ;Homozygote; Chromatography, High Pressure Liquid
Full-Text [PDF 206 kb]   (1814 Downloads)    
Type of Study: Research | Subject: Special
Received: 2013/03/9
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Gupta R, Verma S, Bhargava M, Mittal S. Homozygous delta-beta Thalassemia in a Child: a Rare Cause of Elevated Fetal Hemoglobin. Iran J Ped Hematol Oncol. 2013; 3 (1) :46-41
URL: http://ijpho.ssu.ac.ir/article-1-106-en.html

Volume 3, Issue 1 (3-2013) Back to browse issues page
Iranian Journal of Pediatric Hematology and Oncology
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