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:: Volume 4, Number 1 (3-2014) ::
Iran J Ped Hematol Oncol 2014, 4(1): 17-21 Back to browse issues page
Association between serum ferritin level, cardiac and hepatic T2-star MRI in patients with major β-thalassemia
Dr A Eghbali , Dr H Taherahmadi, Dr M Shahbazi, Dr B Bagheri, Mrs L Ebrahimi
Abstract:   (2083 Views)
Background Frequent blood transfusion is often associated with iron overload. Proper use of iron chelators to treat iron overload requires an accurate measurement of iron levels. Magnetic resonance T2-star (T2* MRI) can measure iron level in the heart and liver. Our goal was to see whether an association exists between serum ferritin level and T2* MRI in patients with major beta thalassemia. Materials and Methods Sixty patients with a diagnosis of major beta thalassemia were enrolled in the study. They were older than five years old and needed regular transfusion. Cardiac and hepatic T2*MRI and mean serum ferritin levels were measured within 3 months. Results No significant correlation was observed between serum ferritin level and cardiac T2*MRI (p=0.361, r=-0.120).However, a significant correlation was observed between serum ferritin and liver T2*MRI (p=0.021, r=-0.297). Conclusion Our results showed an association between hepatic T2*MRI and serum ferritin level.
Keywords: Ferritin, Major thalassemia, T2*MRI, iron chelator
Full-Text [PDF 105 kb]   (887 Downloads)    
Type of Study: Research | Subject: Special
Received: 2014/03/15 | Accepted: 2014/03/15 | Published: 2014/03/15
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Eghbali A, Taherahmadi H, Shahbazi M, Bagheri B, Ebrahimi L. Association between serum ferritin level, cardiac and hepatic T2-star MRI in patients with major β-thalassemia. Iran J Ped Hematol Oncol. 2014; 4 (1) :17-21
URL: http://ijpho.ssu.ac.ir/article-1-153-en.html
Volume 4, Number 1 (3-2014) Back to browse issues page
Iranian Journal of Pediatric Hematology and Oncology
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