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:: Volume 4, Number 3 (9-2014) ::
Iran J Ped Hematol Oncol 2014, 4(3): 97-102 Back to browse issues page
Clinicopathologic characteristics and outcome of childhood and adolescent Ewing’s sarcoma in center of Iran
Dr A Akhavan, Dr F Binesh , Dr A Hashemi, Dr H Shamshiri
Abstract:   (1031 Views)
Background Ewing’s sarcoma family is a group of small round cells tumors. The aim of this study is to evaluate clinicopathologic characteristics and outcome of Ewing’s sarcoma in children and adolescents in Yazd, Iran. Materials and Methods All patients under 19 years with documented pathology of Ewing’s sarcoma family tumor who referred to Shahid Ramazanzadeh Radiotherapy center between 2002 to 2010 were enrolled in this retrospective study. Overall survival and disease free survival and prognostic factors were evaluated. Results Among approximately 80,000 patients who referred to Shahid Sadoughi pathology department, over an 8-year period, the total number of patients with Ewing sarcoma was 32, of which, 18 cases were under the age 19 . The mean age was 13.72 years. Five patients (27.8%) had metastatic disease at the time of diagnosis. Complete response had been achieved in 8 (44.4%) of the patients. Local recurrence occurred in 4 (22.2%) of the patients. During the follow up 13 (72.2%) of the patients showed metastases. The mean overall survival was 34.79 months (95% CI: 22.27-47.32) .One, two, four and five year survival was 72%, 39%, 25% and 17% respectively. Complete remission occurred in 10 patients (63.6%). A trend of better overall survival was found in these patients (p=0. 55). When the brain and bone metastases occurred, the overall survival decreased significantly (p=0. 003 ). Conclusions The overall survival rate of Ewing's sarcoma is very low in comparison with other parts of the world.
Keywords: Ewing’s sarcoma, Survival, Child, Iran
Full-Text [PDF 201 kb]   (356 Downloads)    
Type of Study: Research | Subject: Special
Received: 2014/09/11 | Accepted: 2014/09/11 | Published: 2014/09/11
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Akhavan A, Binesh F, Hashemi A, Shamshiri H. Clinicopathologic characteristics and outcome of childhood and adolescent Ewing’s sarcoma in center of Iran. Iran J Ped Hematol Oncol. 2014; 4 (3) :97-102
URL: http://ijpho.ssu.ac.ir/article-1-171-en.html
Volume 4, Number 3 (9-2014) Back to browse issues page
Iranian Journal of Pediatric Hematology and Oncology
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