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:: Volume 1, Number 1 (11-2010) ::
Iran J Ped Hematol Oncol 2010, 1(1): 19-23 Back to browse issues page
Frequency of Tumor Lysis Syndrome in Aggressive and Slow Introduction Chemotherapy in Children with ALL
Azam Sadat Hashemi , Najme Shahvazian, Asghar Zarezade, Mehrdad Shakiba, Atef Atefi
Abstract:   (3550 Views)
Abstract Background Tumor Lysis Syndrome (TLS) is an oncologic emergency that results from massive lysis of malignant cells. The incidence of TLS depends on the risk factors, such as baseline hyperuricemia, bulky tumor burden, elevated serum LDH, and elevated WBC. The objectives of the present study were to assess frequency of Tumor Lysis Syndrom in children with ALL in two methods of induction chemotherapy, aggressive and slow induction. Materials and Methods In this double blind randomized interventional study, the number of 60 ALL patients in the Shahid Sadoughi Hospital Yazd were studied. They randomly treated using two various methods 30 patients by invasive and 30 by slow induction chemotherapy. Results From 60 patients, 10 cases (16.6%) developed Tumor lysis syndrome. Seven of 10 treated by aggressive chemotherapy and remaining 3 by slow chemotherapy. No significant differences were found (PV= 0.166) between them. Conclusion Based on this study there was no significant difference between Tumor Lysis Syndrom in aggressive induction chemotherapy and slow induction, but WBC and LDH levels before treatment can predict Tumor Lysis Syndrom.
Keywords: ALL, Tumor Lysis Syndrome, Induction Chemotherapy
Full-Text [PDF 117 kb]   (1063 Downloads)    
Type of Study: Research | Subject: Special
Received: 2012/02/21
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Hashemi A S, Shahvazian N, Zarezade A, Shakiba M, Atefi A. Frequency of Tumor Lysis Syndrome in Aggressive and Slow Introduction Chemotherapy in Children with ALL. Iran J Ped Hematol Oncol. 2010; 1 (1) :19-23
URL: http://ijpho.ssu.ac.ir/article-1-25-en.html
Volume 1, Number 1 (11-2010) Back to browse issues page
Iranian Journal of Pediatric Hematology and Oncology
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