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:: Volume 6, Number 3 (9-2016) ::
Iran J Ped Hematol Oncol 2016, 6(3): 157-165 Back to browse issues page
Effect of Sodium Bicarbonate and Sodium Chloride on Renal and Hematologic Factors in Patients with Glucose-6-phosphate Dehydrogenase Deficiency
Dr Narges Beigom Mirbehbahani, Dr Aysan SalamiKhanshan, Dr Baranak Safaian, Dr Sakineh Mohammadian, Dr Nasser behnampour, Dr Safa Ariannejad, Dr Ali Reza Masoomnia, Ms Azin Malekmarzban, DR Azam Rashidbaghan
PhD Ph.D Candidate, Cellular and Molecular Biology, Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Abstract:   (1360 Views)

Abstract

Background: Sodium bicarbonate serum therapy is used for compensation bicarbonate lost and increasing blood pH in metabolic acidosis caused by severe anemia in patient with glucose-6-phosphate dehydrogenase (G6PD) deficiency. The aim of present study was comparison the effect of serum therapy using two different serums (serum with bicarbonate and without bicarbonate) on some renal and hematologic factors and their side effects in patients with hemolysis caused by G6PD deficiency.

Materials and Methods: In this clinical trial study, 79 patients with favism randomly put into two treatment groups, sodium bicarbonate and sodium chloride fluid therapy. During treatment, patients received blood based on hemoglobin (Hb). Duration of hospitalization, times of Blood transfusion, received blood volume, duration of cleaning UA of Hb, Hb, urine pH and granular casts in UA were evaluated.

Results: The mean age of patients was 51.22 ± 37.86 months and there were 58 males and 21 females. Only duration of hospitalization and urine pH statistically showed a significant difference between two treatment groups (P=0.036 and P> 0.01, respectively), and other factors were statistically almost identical.

Conclusion: The efficiency of sodium chloride was more than sodium bicarbonate in reducing the duration of hospitalization and the small clinical difference between received blood volumes, hemoglobin changes and duration of removing hemoglobin in UA, suggest, properly, sodium chloride can be more effective on improvement of hemolysis. Lack of side effects such as metabolic acidosis, heart damage and kidney failure in children can be due to controlled injection method, the concentration of soluble drugs and small size of studied population.

Keywords: Keywords: G6PD, Favism, Hemolysis, Hemolytic Anemia, Sodium Bicarbonate
Full-Text [PDF 131 kb]   (539 Downloads)    
Type of Study: Research | Subject: Special
Received: 2016/03/9 | Accepted: 2016/07/28 | Published: 2016/09/3
References
1. Luzzatto L, Metha A, Vulliamy T. Glucose 6-phosphate dehydrogenase deficiency. In: Scriver CR, Sly WS, Childs B, Beaudet AL, Valle D, Kinzler KW, et al. The metabolic and molecular bases of inherited disease. Columbus, McGraw-Hill, 2001; 4517–53. [Article]
2. Farhud DD, Yazdanpanah L. Glucose-6-phosphate dehydrogenase (G6PD) Deficiency. Iranian J Publ Health. 2008; 37 (4): 1-18. [Article]
3. Mehta A, Mason PJ, Vulliamy TJ. Glucose-6-phosphate dehydrogenase deficiency. Baillieres Best Pract Res Clin Haematol. 2000; 13: 21-38. [Article]
4. Cordes W. Experiences with plasmochin in malaria. In: Anonymous. 15th Annual Report. Boston, MA: United Fruit Co, 1926: 66-71. [Article]
5. Wijk RV, Huizinga EG, Prins I, Kors A, Rijksen G, Bierings M, et al. Distinct phenotypic expression of two denovomissense mutations affecting the dimmer interface of glucose-6-phosphate dehydrogenase. Blood Cells Mol Dis. 2004; 32: 112-117. [Article]
6. Beutler E. G6PD deficiency. Blood. 1994; 84(11): 3613-3636. [Article]
7. Mohanty D, Mukherjee MB, Colah RB. Glucose-6-phosphate dehydrogenase deficiencyin India. Symposium 2004; 71(6): 525-529. [Article]
8. Noori-Daloii MR, Najafi L, Ganji SM, Hajebrahimi Z, Sanati MH. Molecular identification of mutations in G6PD gene in patients with favism in Iran. J Physiol Biochem. 2004; 60: 273-277. [Article]
9. Cappllini MD, Florelli G. Glucose-6-phosphate dehydrogenase deficiency. Lancet. 2008; 21: 64-74. [Article]
10. Darbandi B, Noghbaei M, Mehrabian F, Jafroodi M. Medical expenses of patients with Favism admitted to 17th Shahrivar Hospital compared to G6PD enzyme screening cost, in north of Iran. Iran J Ped Hematol Oncol. 2014; 4 (2): 53-56. [Article]
11. Boskabadi H, Omidian M, Mafinejad SH. Prevalence and clinical manifestation of glucose-6-phosphate dehydrogenase deficiency in newborns with hyperbilirubinemia in Mashhad, Iran. MJMS. 2010; 3 (4): 383-387. [Article]
12. WHO Working Group. Glucose-6-phosphate dehydrogenase deficiency. Bull WHO 1989; 67: 601-611. [Article]
13. Mesbah-Namin SA, Sanati MH, Mowjood A, Mason PJ, Vulliamy TJ, Noori-Daloii MR. Three major glucose-6-phosphate dehydrogenase - deficient polymorphic variants identified in Mazandaran state of Iran. Br J Haematol. 2002; 117: 763-764. [Article]
14. Mortazavi Y, Mirimoghaddamm E, Pourfathollah AA. 8th Annual Congress of the Europian Hematology Association. Hematol J. 2003; 4: 15. [Article]
15. Pishva N, Amoozgar H. Hyperbilirubinemia following exchange transfusion with G6PD deficient donor blood. Ir J Med Sci. 2001; 26: 143-145. [Article]
16. Zager RA. Rhabdomyolysis and myohemoglobinuric acuterenal failure. Kidney Int. 1996; 49: 314–326. [Article]
17. Kanaan A, Douglas RM, Alper SL, Boron WF, Haddad GG. The effect of chronic elevated carbon dioxide on the expression ofacid-base transporters in the neonatal and adult mouse. Am J Physiol Regul Integr Comp Physiol. 2007; 293 (3): R1294–1302. [Article]
18. Aschner JL, Poland RL. Sodium Bicarbonate: Basically Useless Therapy. Pediatrics. 2008; 122: 831-835. [Article]
19. Szeto CHCH, Wong TYH, Chow KM, Leung CHB, Li PHKT. Oral sodium bicarbonate for the treatment of metabolic acidosis in peritoneal dialysis patients: a randomized placebo-control trial. J Am Soc Nephrol. 2003; 14: 2119-2126. [Article]
20. Merten GJ, Butgess WP, Gray LV, Holleman JH, Roush TS, Kowalchuk GJ, et al. Prevention of contrast-induced nephropathy with sodium bicarbonate: a randomized controlled trial. JAMA. 2004; 291(19): 2328-2334. [Article]
21. Masuda M, Yakahisa Y, Okuyama Y, Morita T, Sanada S, Furukawa Y. Sodium bicarbonate improves long-term clinical outcomes compared with sodium chloride in patients with chronic kidney disease undergoing an emergent coronary procedure. Circ J. 2008; 72: 1610-1614. [Article]
22. Forsythe SM, Schmidt GA. Sodium bicarbonate for the treatment of lactic acidosis. Chest. 2000; 117(1): 260-267. [Article]
23. Macdante KJ, Kliegman RM. Nelson essential of pediatrics. 7th edition, Elsevier Sunders, 2015. [Article]
24. Orkin SH, Nathan DG, Ginsburg D, Look AT, Fisher DE, Lux S. Nathan and Oski's Hematology of Infancy and Childhood. 7th edition, Elsevier Sunders, Philadelphia, 2009. [Article]
25. Dhaliwal G, Cornett PA, Tierney LM. Hemolytic anemia. Am Fam Physician 2004; 69 (11): 2599-5606. [Article]
26. Donoso G, Hedayat H, Khayatian H. Favism with special reference to Iran. Bull World Health Organ.1969; 40: 513-519. [Article]
27. Elyassi CAR, Rowshan MHH. Prospective management of the glucose-6-phosphate dehydrogenase deficient patient: a review of literature. Anesth Prog 2009; 56: 86-91. [Article]
28. Schurman M, Waardenburg DV, Costa JD, Niemarket H, Leroy P. Sever hemolysis and methemoglobinemia following fava beans ingestion in glucose-6-phosphate dehydrogenase deficiency- case report and literature review. Eur J Pediatr. 2009; 168: 779-782. [Article]
29. Buckley EM, Naim MY, Lynch JM, Goff DA, Schwab PJ, Diaz LK, et al. Sodium bicarbonate causes dose-dependent increases in cerebral blood flow in infants and children with single-ventricle physiology. Pediatr Res. 2013; 73 (5): 668-673. [Article]
30. Meyers R.S. Pediatric Fluid and Electrolyte Therapy. J Pediatr Pharmacol Ther. 2009; 14, 204–211. [Article]
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Mirbehbahani N B, SalamiKhanshan A, Safaian B, Mohammadian S, behnampour N, Ariannejad S, et al . Effect of Sodium Bicarbonate and Sodium Chloride on Renal and Hematologic Factors in Patients with Glucose-6-phosphate Dehydrogenase Deficiency. Iran J Ped Hematol Oncol. 2016; 6 (3) :157-165
URL: http://ijpho.ssu.ac.ir/article-1-265-en.html
Volume 6, Number 3 (9-2016) Back to browse issues page
Iranian Journal of Pediatric Hematology and Oncology
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