Volume 6, Issue 4 (11-2016)                   Iran J Ped Hematol Oncol 2016, 6(4): 228-234 | Back to browse issues page

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Ghassemi A, Badiee Z, Farhangi H, Banihashem A, Syedi S J, Ghodsi R, et al . Evaluation of Efficacy of Varicella Vaccine in Pediatric Patients with Acute lymphoblastic Leukemia . Iran J Ped Hematol Oncol. 2016; 6 (4) :228-234
URL: http://ijpho.ssu.ac.ir/article-1-276-en.html
Associate Professor of pediatric hematology & oncology, Mashhad University of medical Sciences, Mashhad , Iran
Abstract:   (3501 Views)



Varicella is a highly contagious and dangerous disease especially in immunocompromised patients. Children with cancer are at increased risk of severe illness and may fatal cases occur. Vaccination from VZV ( varicella zoster vaccine) infection can be safe, immunogenic, and effective in children with leukemia who meet the criteria and are at the risk of serious disease or death. The aim of this study was   investigate the efficacy of vaccines VZV on pediatric patients with Acute Lymphoblastic Leukemia

Materials and Methods:

The study was performed on 46 ALL children aged between 1to15 years old who underwent chemotherapy. Considering the efficacy of vaccines on pediatric patients the title serum sample of IgG-anti-VZV avidity was determined using a test kit before and after the injection of vaccines VZV.


A total of 46 patients were included analysis. Their title serum sample IgG were negative before the injection of  vaccines VZV and after receiving VZV vaccine with respect to title serum sample IgG atatus,  31 (67.4%) patients were positive and 15 (32.6%) patients were negetive. No significant was observed association between either title of IgG-anti-VZV after receiving of VZV vaccine and gender (P = 1.0) title of IgG-anti-VZV and age groups (P =0.387).


Regarding the obtained results, it can be concluded that varicella vaccination can have an acceptable effectiveness on pediatric patients with ALL. Varicella vaccination can be recommended for protecting these patients against VZV in order to decrease the morbidity rate caused by this infection. 

Full-Text [PDF 188 kb]   (635 Downloads)    
Type of Study: Research | Subject: Special
Received: 2016/01/13 | Accepted: 2016/04/26 | Published: 2016/10/30

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