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:: Volume 7, Issue 3 (7-2017) ::
Iran J Ped Hematol Oncol 2017, 7(3): 180-192 Back to browse issues page
The Efficacy of Toll-Like Receptors in Awakening Dendritic Cell/Natural Killer Cell System for Eradication of Tumors
Fatemeh Pourrajab Dr, Parisa i Yazdani Elahabad Dr, Seyedhossein Hekmatimoghaddam Dr
PhD Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract:   (126 Views)

Natural killer (NK) cells are effector cells of the innate immune system that exert direct cytotoxic functions. Ubiquitously-expressed toll-like receptors (TLRs) have been recognized as one of the major components promoting dendritic cell (DC) maturation, which may induce polarized immune responses beneficial to cancer immunotherapy. TLR-activated NK cells and DCs are prerequisite for robust activation of the innate immune system against tumors. Recently, some medical research and clinical trials have proposed NK cells as a new therapy and potential strategy in both children and adults with those cancers which cannot be cured with the usual treatment modalities. As an example, the importance of DC/NK antitumor immunity in the outcome of breast and other cancers is recently recognized. Therefore, considering strategies which exploit TLR-mediated immunity in concordance with DC/NK system holds strong potential for cancer therapy. This review addresses the current knowledge about the potential role of TLR in tumor immunotherapy

Keywords: Dendritic Cell, Immune System, Natural Killer Cell, Toll-like Receptor, Tumor
Full-Text [PDF 382 kb]   (57 Downloads)    
Type of Study: Research | Subject: Special
Received: 2016/01/24 | Accepted: 2016/10/28 | Published: 2017/07/16
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Pourrajab F, Yazdani Elahabad P I, Hekmatimoghaddam S. The Efficacy of Toll-Like Receptors in Awakening Dendritic Cell/Natural Killer Cell System for Eradication of Tumors. Iran J Ped Hematol Oncol. 2017; 7 (3) :180-192
URL: http://ijpho.ssu.ac.ir/article-1-324-en.html
Volume 7, Issue 3 (7-2017) Back to browse issues page
Iranian Journal of Pediatric Hematology and Oncology
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