Volume 10, Issue 1 (1-2020)                   Iran J Ped Hematol Oncol 2020, 10(1): 57-68 | Back to browse issues page

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Hashemieh M. Early Detection of Renal Dysfunction in β Thalassemia with Focus on Novel Biomarkers. Iran J Ped Hematol Oncol. 2020; 10 (1) :57-68
URL: http://ijpho.ssu.ac.ir/article-1-513-en.html
Imam Hossein Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:   (528 Views)
Improved survival among transfusion dependent thalassemia patients in recent years has led to the manifestation of morbidities such as renal dysfunction. Renal injury is still an underestimated complication in β thalassemia major patients. Chronic anemia, iron overload due to repeated transfusion, and specific iron chelators are the main factors in pathogenesis of renal dysfunction in β thalassemia. Early identification of this morbidity allows us to delay the progression of kidney damage and therefore reduce renal impairment. In recent decades , novel biomarkers for early recognition of renal dysfunction have been studied in thalassemic patients, such as cystatin C, beta 2 microglobulin , alpha 1 microglobulin, N-acetyl beta-D-glucosaminidase (NAG), neutrophil gelatinase associated lipocaline (NGAL) , kidney injury molecule 1 (KIM-1) , liver type fatty acid binding protein (L-FABP), and retinol binding protein (RBP). In this review, renal aspects of thalassemia with focus on novel biomarkers were discussed.
Full-Text [PDF 386 kb]   (271 Downloads)    
Type of Study: Research | Subject: General
Received: 2019/05/29 | Accepted: 2019/09/25 | Published: 2020/01/6

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