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:: Volume 2, Issue 4 (12-2012) ::
Iran J Ped Hematol Oncol 2012, 2(4): 133-139 Back to browse issues page
Assessment of antibody titers and immunity to Hepatitis B in children receiving chemotherapy
A Shams Shahemabadi PhD , F Salehi BSc, A Hashemi MD, M Vakili MD, F Zare MSc, N Esphandyari MD, S Kashanian MSc
Abstract:   (2939 Views)
Abstract Background There is a decrease in vaccine-specific antibody to certain vaccine-preventable diseases in children after chemotherapy, but the frequency of non-immune patients is not clear. In the present case-control study, was taken under investigation protection level to Hepatitis B infection in children 6 months after completing chemotherapy. Materials and Methods In this study 68 patients with cancer and 68 healthy children were enrolled. Patients were 1.5 -12 years old with completed standard chemotherapy at least for 6 months. All the patients and healthy children were negative for HBsAg and HBeAg and had received Hepatitis B vaccination. IgG antibody concentrations against Hepatitis B Virus (HBV) were determined in the patients receiving chemotrapy and healthy subjects serum by ELISA method. IgG antibody titer > 10 mIU/ml was considered as baseline protective titer for preventing HBV infection. Results Anti-HBs antibody titer in 19.12% of patients was less than 10 mIU/ml and 11.76% of the patients had borderline antibody titer (10-20 mIU/ml). In healthy subjects, 2.94% and 5.88% had antibody titer < 10 mIU/ml and 10-20 mIU/ml, respectively. According to statistical analysis, frequency of non immune subjects in children with cancer was significantly higher than those in healthy children (P-value=0.024). Conclusion HBV vaccination post-intensive chemotherapy in the children with cancer is strongly recommended.
Keywords: Hepatitis B, Vaccination, Immunity
Full-Text [PDF 181 kb]   (825 Downloads)    
Type of Study: Research | Subject: Special
Received: 2012/12/19
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Shams Shahemabadi A, Salehi F, Hashemi A, Vakili M, Zare F, Esphandyari N et al . Assessment of antibody titers and immunity to Hepatitis B in children receiving chemotherapy. Iran J Ped Hematol Oncol. 2012; 2 (4) :133-139
URL: http://ijpho.ssu.ac.ir/article-1-86-en.html

Volume 2, Issue 4 (12-2012) Back to browse issues page
Iranian Journal of Pediatric Hematology and Oncology
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