Fri, Jun 19, 2026
[Archive]
Volume 16, Issue 3 (6-2026)
Iran J Ped Hematol Oncol 2026, 16(3): 922-933 |
Back to browse issues page
Ethics code: IR.SSU.MEDICINE.REC.1401.134
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Roknaldini M, Vajihinejad M. Clinicopathological Features, Prognostic Factors, and Survival Outcomes of Retroperitoneal Lesions. Iran J Ped Hematol Oncol 2026; 16 (3) :922-933
URL: http://ijpho.ssu.ac.ir/article-1-1017-en.html
URL: http://ijpho.ssu.ac.ir/article-1-1017-en.html
Department of Pathology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran & Department of Pathology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
Abstract: (19 Views)
Background: Retroperitoneal tumors (RPTs) are rare and heterogeneous neoplasms that show distinct biological and clinical features across age groups. This study aimed to assess the clinicopathological characteristics of RPTs in pediatric and adult patients.
Materials and Methods: This retrospective cohort study included patients diagnosed with RPTs from 2016 to 2021. The clinical data, histopathological findings, and outcomes were reviewed and compared between the children (< 18 years) and adults (≥ 18 years). Statistical analyses were performed using chi-square and Fisher’s exact tests, independent t-tests, Kaplan–Meier survival analysis, and Firth’s penalized logistic regression.
Results: Among 109 patients, 14 (12.8%) were children and 95 (87.2%) were adults. Metastatic tumors were the most common lesion type (72.5%), followed by primary malignant (21.1%) and benign tumors (6.4%). Metastatic tumors were the predominant histopathological category (72.5%), followed by primary malignant mesenchymal tumors (16.5%). Histopathological distributions were similar between children and adults, with no significant differences observed across categories (all p>0.05). Overall survival was similar between children and adults (p=0.35). Abdominal pain was the most common symptom (51.4%), while nausea occurred more frequently in children (p=0.01). Firth’s penalized logistic regression identified no significant associations between clinicopathological factors and recurrence or necrosis (all p>0.05).
Conclusion: Metastatic tumors predominated in both age groups, followed by primary malignant mesenchymal tumors. No significant age-related differences were observed in histopathological categories, tumor origin, or survival.
Materials and Methods: This retrospective cohort study included patients diagnosed with RPTs from 2016 to 2021. The clinical data, histopathological findings, and outcomes were reviewed and compared between the children (< 18 years) and adults (≥ 18 years). Statistical analyses were performed using chi-square and Fisher’s exact tests, independent t-tests, Kaplan–Meier survival analysis, and Firth’s penalized logistic regression.
Results: Among 109 patients, 14 (12.8%) were children and 95 (87.2%) were adults. Metastatic tumors were the most common lesion type (72.5%), followed by primary malignant (21.1%) and benign tumors (6.4%). Metastatic tumors were the predominant histopathological category (72.5%), followed by primary malignant mesenchymal tumors (16.5%). Histopathological distributions were similar between children and adults, with no significant differences observed across categories (all p>0.05). Overall survival was similar between children and adults (p=0.35). Abdominal pain was the most common symptom (51.4%), while nausea occurred more frequently in children (p=0.01). Firth’s penalized logistic regression identified no significant associations between clinicopathological factors and recurrence or necrosis (all p>0.05).
Conclusion: Metastatic tumors predominated in both age groups, followed by primary malignant mesenchymal tumors. No significant age-related differences were observed in histopathological categories, tumor origin, or survival.
Type of Study: Research |
Subject:
General
Received: 2025/12/4 | Accepted: 2026/06/7 | Published: 2026/06/17
Received: 2025/12/4 | Accepted: 2026/06/7 | Published: 2026/06/17
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
