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Abstract Background A vast variety of factors may cause recurrent pregnancy loss. Blood group incompatibility of parents could cause abortion. The examination of couples or twins, blood groups showed that the blood group incompatibility can affect adversely the outcome of pregnancy. Couples with blood group incompatibility are more involved in spontaneous miscarriage. Antigenes in two different blood groups could disorganize implantation. Aborted embryos with normal karyotype showed more frequently blood group incompatibility with their mother. Abnormal newborn and stillbirth were observed more frequent in couples with incompatible blood groups than without. Methods This study investigates relationship between blood groups incompatibility and recurrent miscarriage in couples who were referred to genetic counseling clinic of Yazd Research & Clinical Center for Infertility. The blood group of 100 couples with recurrent miscarriage was evaluated using slide test method. Their abortions were unknown after possible evaluation. One hundred and twelve fertile couples entered to this study as control group, which have at least two normal children without any abortion. Results The results showed blood group incompatibility was more frequent in couples with recurrent abortion than fertile couples. Conclusion Blood group incompatibility of parents could causes antigen-antibody interaction between mother and fetus, which ended with abortion. In previous study it was believed that blood group incompatibility cases fetal anemia and stillbirth.

Keywords: Blood groups incompatibility, Recurrent miscarriage, Antigen-antibody

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