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Iran J Ped Hematol Oncol 2025, 15(4): 647-660 |
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Ethics code: IR.ZAUMS.REC.1399.373
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Noori N M, Miri Aliabad G, Boryri T, Teimouri L, Sapour Moghadam S, Teimouri A. The Effect of Iron Therapy on Electrocardiography Parameters in Children with Iron Deficiency Anemia. Iran J Ped Hematol Oncol 2025; 15 (4) :647-660
URL: http://ijpho.ssu.ac.ir/article-1-903-en.html
URL: http://ijpho.ssu.ac.ir/article-1-903-en.html
The Effect of Iron Therapy on Electrocardiography Parameters in Children with Iron Deficiency Anemia
Noor Mohammad Noori 
, Ghasem Miri Aliabad , Tahereh Boryri , Leila Teimouri , Sahar Sapour Moghadam , Alireza Teimouri *
, Ghasem Miri Aliabad , Tahereh Boryri , Leila Teimouri , Sahar Sapour Moghadam , Alireza Teimouri *
Associate Professor of Demography, Children and Adolescents Health research center, Research Institute of cellular and Molecular Science in Infectious Diseases, Zahedan University of Medical Science's, Zahedan, Iran & Associate Professor of Demography, Children and Adolescents Health research center, Research Institute of cellular and Molecular Science in Infectious Diseases, Zahedan University of Medical Science's, Zahedan, Iran
Abstract: (12 Views)
Background: Iron is essential for hemoglobin (Hb) production and the body's ability to transport oxygen. This study aimed to evaluate the impact of iron deficiency anemia (IDA) on electrocardiographic (ECG) parameters in children.
Materials and Methods: This pre–post interventional study was carried out at Ali Asghar Hospital in Zahedan and included children aged 5 to 18 years diagnosed with IDA. For each participant, hematologic markers Hb, ferritin, serum iron, and total iron-binding capacity (TIBC) were assessed. In addition, ECG indices, including P wave duration (PWd), QT interval dispersion (QTd), corrected QT interval (QTc), Tp-e interval, and Tp-e dispersion, were recorded both at baseline and after three months of iron therapy.
Results: A total of 45 children (mean age: 11.47 ± 4.00 years) participated in the study. After three months of treatment with 4–6 mg/kg/day of elemental iron, significant improvements were observed in several hematological and ECG parameters, including ferritin, serum iron, TIBC, P wave duration, P wave dispersion, QTc, QTc dispersion, Tp-e interval, Tp-e dispersion, and the Tp-e/QTc ratio (p < 0.001). In children with Hb levels between 10 and 11 g/dL, all ECG parameters improved significantly (p < 0.001), while those with Hb levels between 8 and 9 g/dL showed significant improvement in all parameters except the Tp-e/QTc ratio (p = 0.002). Among children with ferritin levels >10 ng/mL, all ECG parameters improved (p < 0.001), whereas in those with ferritin ≤10 ng/mL, all but QTc showed significant changes (p =0.002). Serum iron levels between 15 and 20 µg/dL were associated with improvements in all evaluated parameters (p = 0.002), while those with levels between 21 and 28 µg/dL demonstrated significant changes only in TIBC and P wave duration (p = 0.002).
Conclusion: The study concluded that the Iron supplementation positively impacts hematological and ECG parameters, supporting heart health in children.
Materials and Methods: This pre–post interventional study was carried out at Ali Asghar Hospital in Zahedan and included children aged 5 to 18 years diagnosed with IDA. For each participant, hematologic markers Hb, ferritin, serum iron, and total iron-binding capacity (TIBC) were assessed. In addition, ECG indices, including P wave duration (PWd), QT interval dispersion (QTd), corrected QT interval (QTc), Tp-e interval, and Tp-e dispersion, were recorded both at baseline and after three months of iron therapy.
Results: A total of 45 children (mean age: 11.47 ± 4.00 years) participated in the study. After three months of treatment with 4–6 mg/kg/day of elemental iron, significant improvements were observed in several hematological and ECG parameters, including ferritin, serum iron, TIBC, P wave duration, P wave dispersion, QTc, QTc dispersion, Tp-e interval, Tp-e dispersion, and the Tp-e/QTc ratio (p < 0.001). In children with Hb levels between 10 and 11 g/dL, all ECG parameters improved significantly (p < 0.001), while those with Hb levels between 8 and 9 g/dL showed significant improvement in all parameters except the Tp-e/QTc ratio (p = 0.002). Among children with ferritin levels >10 ng/mL, all ECG parameters improved (p < 0.001), whereas in those with ferritin ≤10 ng/mL, all but QTc showed significant changes (p =0.002). Serum iron levels between 15 and 20 µg/dL were associated with improvements in all evaluated parameters (p = 0.002), while those with levels between 21 and 28 µg/dL demonstrated significant changes only in TIBC and P wave duration (p = 0.002).
Conclusion: The study concluded that the Iron supplementation positively impacts hematological and ECG parameters, supporting heart health in children.
Type of Study: Research |
Subject:
Hematology
Received: 2024/10/11 | Accepted: 2025/09/8 | Published: 2025/09/19
Received: 2024/10/11 | Accepted: 2025/09/8 | Published: 2025/09/19
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